Which is better – tadalafil or sildenafil

Erectile dysfunction can seriously injure a man, which is why all kinds of means are used to treat it. In particular, Tadalafil or Sildenafil are used for therapy .  

Men around the world argue about what is the best way to deal with sexual failure. The answer to this question can be obtained by a simple comparison of characteristics.

To improve potency

An erection is caused by a congestion of blood to the penis . If this does not happen naturally, then doctors recommend using phosphodiesterase inhibitors. Three substances are now known that are found in popular generics: 

  • sildenafil (Viagra);
  • tadalafil (“Cialis”);
  • vardenafil (“Levitra”).

Viagra was the first to appear on the market, and over the years it has earned the title of the legendary PDE-5 inhibitor. The rest appeared a little later, so many consider them to be improved versions. This is partly true, some of the side effects inherent in the popular erection pills are not found in more modern drugs. 

What are the similarities?

All of these drugs are classified as PDE-5 inhibitors. They have a single mechanism, which is why it is very difficult to compare them. After taking the pill, accompanied by stimulation of arousal, nitric oxide is released due to the activation of nerve impulses.

In the smooth muscle walls of blood vessels, guanosine monophosphate accumulates, which triggers biochemical reactions. The end result of the application is an erection.

The first drug to overcome erectile dysfunction was invented to correct heart rate and treat tachycardia, solving sexual problems became a side effect. It was observed in 80% of patients taking the pills.

After doctors received confirmation that an erection can be achieved with the help of pharmacology, they began to develop new PDE-5 inhibitors. They released drugs in which vardenafil and tadalafil act as active substances.

Excellent features

Since the drugs were developed at different times, each new active ingredient discovered had fewer side effects. It did not have a less detrimental effect on the male body. In addition, the possible frequency of reception also changed. Tadanafil, unlike its predecessors, can be used daily.

They differ in several features, the main one being the power of action. Some of them activate faster, while others are best taken before a romantic dinner. If you are used to having several sexual acts in one night, then you need to drink drugs for impotence, which stimulate blood flow to the pelvic organs for a long time.

Using any of the PDE5 inhibitors is a good way to deal with a lack of erection or impotence.

It is important to understand that the drug itself will not work. In order for an erection to occur, masturbation or foreplay is necessary before intercourse. Erotic films help to achieve excitement well.

Sildenafil Review

The first to be discovered was Sildenafil, which is better known by the name of its generic drug Viagra. It was this drug that was first used to treat tachycardia, and then began to be used against erectile dysfunction. It has several features:

  • you need to take it 1-3 hours before sexual intercourse;
  • you should not drink alcohol on this day; 
  • fatty foods reduce the potency of the drug.

Interaction with other drugs in Viagra is worse than in other similar drugs. It categorically cannot be combined with nitrates, nitric oxide donors and nitrites. According to reviews, side effects of Sildenafil are extremely rare, but they cause more anxiety. Many patients noted that their visual acuity decreased after taking the medication.

Tadalafil’s overview

This erectile dysfunction remedy hit the shelves in 2003 under the name Cialis. It was positioned as a new long-acting PDE-5 inhibitor. These pills have become a real salvation for many married couples, since with their help you can forget about the lack of an erection for 36 hours.  

Some patients refer to Tadalafil as weekend pills. Their effect is valid for 2 nights.

Another advantage of the new inhibitor is the ability to take fatty foods with it. He often has side effects that make treatment pointless – patients suffer from headaches and back discomfort. Pharmacists also failed to avoid visual impairments – some men experience pain in the eyes and impaired color perception.

Overview of Vardenafil

In 2005, “Levitra” appeared on the shelves of pharmacies, its active ingredient was the inhibitor vardenafil. The main goal of pharmacists in its development was to reduce the risk of side effects. At the same time, they strove to maintain the high efficiency of the drug.

The developers managed to achieve their goals. Vardenafil is activated within 20 minutes after administration, and acts no less than the more common Viagra. Side effects occur in only 2% of patients. Thanks to this, the relatively new drug “Levitra” has become popular among men.

What is the best active ingredient?

When choosing between sildenafil, tadalafil or vardenafil, it is necessary to compare the main characteristics.

Evaluation criterionSildenafilTadalafilVardenafil
PeculiaritiesHelps in 82-84% of cases of erectile dysfunction. You must drink on an empty stomach. The maximum concentration in the blood is reached after 2 hours.Effective in 81% of cases of impotence. You can use it regardless of food intake. The maximum concentration in the blood is reached in an hour. The erection increases during intercourse.Has a softer effect. It is permissible to take a small dose of alcohol with it. An erection does not need to be further stimulated, it can arise even from a light touch.
Dosage100-200 mg20-40 mg20-40 mg
How quickly the effect occursYou need to drink in advance – the effect occurs in 90-120 minutes.The average time to the onset of action is 60 minutes.A strong erection appears in 20-30 minutes.
Side effectredness of the face, neck;stuffy nose and ears;changes in blood pressure levels;deterioration of vision;nausea and heartburn.It is observed in 9% of patients.muscle pain;dyspepsia;swelling of the eyelids;redness of the face;pain in the eyes and inflammation of the conjunctiva;darkening in the eyes, dizziness.Observed in 3% of patients.improper functioning of the hematopoietic and urinary systems;dysfunction of the central nervous system and hepatobiliary system.Observed in 2% of cases.
ContraindicationsAllergies, disorders of the heart and blood vessels, liver or kidney disease, gastrointestinal ulcers, heart attack or stroke that occurred in the last few months.Leukemia, allergies, malfunctioning of the hematopoietic systems, nervous or cardiovascular, anatomical deformation of the penis, degeneration of the retina.Atherosclerosis, ailments that have affected the cardiovascular system, allergies, kidney failure, liver disease, ulcers that have affected any of the organs of the digestive system.
Compatibility with other medicinesIt is forbidden along with medications that donate nitric oxide, nitrates and nitrites.Use the product with caution with liver enzymes.

Any of the described drugs is strictly prohibited for women and children. They are also not recommended for men without erection problems.

Reviews of patients and doctors

The choice of a drug must be made based on the individual characteristics of the patient and the effect he wants to achieve. It is almost impossible to compare them, since they completely coincide with the mechanism of manifestations. Based on the feedback from doctors and patients, the following conclusions can be drawn:

  1. Vardenafil should be taken when speed is needed. It is often used for casual sex.
  2. Viagra and Cialis should not be used when you are going to drink alcohol. In this case, Levitra is best suited, which is compatible with it.
  3. Seniors over 65 should also choose vardenafil, although many doctors consider Viagra to be safer.

If you are planning a romantic dinner after which you want to have sex, then it is better to take silnedafil or vardenafil. The first should be taken before meals, and the second can be mixed with a small dose of wine, but it should be consumed after the meal. 

It is impossible to determine which drug will help you, since each of them has its own list of contraindications and side effects. Read the instructions carefully before taking to determine if it is right for you. Only on the basis of this is it worth choosing a remedy. The differences are not very large, but they must be considered before taking medications.

event_note November 26, 2021

account_box Dr. John Provet

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